Mutation
DNA polymerase, an holoenzyme is an important enzyme which replicate DNA….the importance of this enzyme is not to be denied, there wont be any mitosis without this enzyme, and where would we be then?
DNA polymerase adds nucleotides and synthesis DNA, to replicate our genetic material in a way with high efficiency…however accurate and meticulously governed it may be, it cant avoid committing mistakes as well…when it mistakenly matched a pair of nucleotides, a mistake is made..however, with its exonuclease activity to proofread and repair, mistake can be corrected…
i am not new to committing mistakes… and i have the exact ability as DNA pol to detect and rectify the mistakes, another similarity is that, no matter how efficient the mechanism can be, there are times mutation occurs,or the mistake evaded the proofread mechanism… i have one unique feature the enzyme lacks.. i choose to overcome and correct the mistake with bias..thats is why, the mutation is left uncorrected…
